Week 5 of the 2026 NFL season arrives with several major storylines, including an international matchup in London, five divisional games, the first byes of the season and a heavyweight Monday night battle between Buffalo and the Los Angeles Rams.
London Game 9:30 AM Sunday
Philadelphia Eagles at Jacksonville Jaguars
The Eagles and Jaguars meet at Tottenham Hotspur Stadium in the NFL’s Week 5 London game.
Philadelphia is looking to rebound after losing to the Rams, while Jacksonville enters as a strong favourite.
Key matchup: Jacksonville’s defense against Philadelphia’s offense, particularly with Saquon Barkley’s hamstring injury adding uncertainty to the Eagles’ attack.
Prediction: Jaguars 27, Eagles 23
Game of the Week
Buffalo Bills at Los Angeles Rams
Monday night’s matchup could be one of Week 5’s best games.
The Rams are coming off an impressive comeback victory over Philadelphia, while Buffalo suffered a narrow home loss to New England.
The Rams are currently favoured by roughly a field goal, but Buffalo has been competitive as an underdog and enters with a 3-1 ATS record.
Key matchup: Buffalo’s defense vs. the Rams’ explosive passing game.
Prediction: Bills 30, Rams 27
Other Games to Watch
Chicago Bears at Green Bay Packers
A major NFC North rivalry at Lambeau Field.
Chicago enters as a slight road favourite in a fascinating divisional matchup.
Prediction: Bears 27, Packers 24
San Francisco 49ers at Seattle Seahawks
San Francisco is one of the NFL’s remaining unbeaten teams at 4-0, while Seattle is coming off a victory over the Chargers.
The atmosphere at Lumen Field should make this one of Sunday’s toughest road tests.
Prediction: 49ers 27, Seahawks 24
Baltimore Ravens at Atlanta Falcons
This game changed dramatically with Lamar Jackson sidelined by an ankle injury. Tyler Huntley is expected to start for Baltimore.
Prediction: Falcons 24, Ravens 20
Cincinnati Bengals at Miami Dolphins
Cincinnati is favoured by around a touchdown and will look to rebound after a difficult Week 4.
Prediction: Bengals 30, Dolphins 20
Denver Broncos at Los Angeles Chargers
A potentially physical AFC West battle with major early-season implications.
Prediction: Broncos 24, Chargers 21
Detroit Lions at Arizona Cardinals
Detroit needs to bounce back after its surprising Week 4 loss to Carolina.
The matchup has one of the week’s highest projected totals.
Prediction: Lions 34, Cardinals 27
Indianapolis Colts at Pittsburgh Steelers
One of the week’s more intriguing AFC matchups.
Pittsburgh is a narrow favourite, while Indianapolis has a longer injury list heading into the game.
Prediction: Steelers 27, Colts 24
Week 5 Byes
The Kansas City Chiefs and Carolina Panthers are off this week.
Week 5 Predictions
Buccaneers at Cowboys
Cowboys
Eagles at Jaguars
Jaguars
Browns at Jets
Jets
Bengals at Dolphins
Bengals
Raiders at Patriots
Patriots
Vikings at Saints
Vikings
Texans at Titans
Texans
Giants at Commanders
Giants
Colts at Steelers
Steelers
Bears at Packers
Bears
Broncos at Chargers
Broncos
Lions at Cardinals
Lions
49ers at Seahawks
49ers
Ravens at Falcons
Falcons
Bills at Rams
Bills
Bottom line: Week 5 has the potential to significantly reshape the early playoff picture.
The 49ers’ unbeaten start, Lamar Jackson’s injury, the Bears-Packers rivalry and Bills-Rams showdown are the biggest storylines to watch.
