Chicago Bears at Carolina Panthers — 1:00 p.m. ET
Caleb Williams begins another season under significant expectations as Chicago visits Carolina. The Panthers’ revamped offensive line will face an early test against the Bears’ defense.
Prediction: Bears 24, Panthers 20
Baltimore Ravens at Indianapolis Colts — 1:00 p.m. ET
Lamar Jackson leads Baltimore into Indianapolis in one of Week 1’s most intriguing AFC matchups. The Colts will need to contain Jackson’s dual-threat ability while finding ways to pressure the Ravens’ offense.
Prediction: Ravens 30, Colts 23
Atlanta Falcons at Pittsburgh Steelers — 1:00 p.m. ET
Pittsburgh begins the season with major attention surrounding veteran quarterback Aaron Rodgers. Atlanta will attempt to make the Steelers uncomfortable with its athletic offense.
Prediction: Steelers 23, Falcons 20
Cleveland Browns at Jacksonville Jaguars — 1:00 p.m. ET
Jacksonville enters the season with playoff expectations, while Cleveland begins another rebuilding chapter. The Jaguars should have the offensive firepower to control the game.
Prediction: Jaguars 27, Browns 17
Tampa Bay Buccaneers at Cincinnati Bengals — 1:00 p.m. ET
Two playoff hopefuls collide in Cincinnati. Joe Burrow and the Bengals’ passing attack will face a Tampa Bay defense capable of creating problems.
Prediction: Bengals 31, Buccaneers 27
New York Jets at Tennessee Titans — 1:00 p.m. ET
Both clubs are looking for a strong start after offseason changes. Garrett Wilson gives the Jets a dynamic offensive weapon, but Tennessee will have home-field advantage.
Prediction: Jets 24, Titans 21
New Orleans Saints at Detroit Lions — 1:00 p.m. ET
Detroit enters the season with legitimate NFC aspirations. Jahmyr Gibbs and the Lions’ explosive offense could create matchup problems for New Orleans.
Prediction: Lions 30, Saints 20
Buffalo Bills at Houston Texans — 1:00 p.m. ET
This could be one of Week 1’s best games. Josh Allen and Buffalo travel to Houston for a matchup featuring two teams with legitimate AFC championship aspirations.
Prediction: Bills 27, Texans 24
Sunday Afternoon
Arizona Cardinals at Los Angeles Chargers — 4:25 p.m. ET
Justin Herbert and the Chargers begin the season at home against Arizona. Los Angeles has the quarterback advantage and should be expected to dictate the pace.
Prediction: Chargers 28, Cardinals 17
Green Bay Packers at Minnesota Vikings — 4:25 p.m. ET
An NFC North rivalry immediately highlights Week 1. Green Bay’s defense could be the difference in what should be a physical game.
Prediction: Packers 24, Vikings 21
Miami Dolphins at Las Vegas Raiders — 4:25 p.m. ET
Miami’s speed gives the Dolphins a significant advantage, but Las Vegas should benefit from playing at home. This could become a high-scoring affair.
Prediction: Dolphins 30, Raiders 24
Washington Commanders at Philadelphia Eagles — 4:25 p.m. ET
An NFC East rivalry opens the season with Philadelphia defending home turf. Jalen Hurts and the Eagles’ offense will be heavily tested by Washington.
Prediction: Eagles 28, Commanders 23
Sunday Night Football
Dallas Cowboys at New York Giants — 8:20 p.m. ET
Few Week 1 games carry more rivalry history. The Cowboys and Giants renew their NFC East rivalry in prime time, with both teams eager to make an immediate statement.
Dallas’ offensive talent could prove decisive, but New York should keep the game close.
Prediction: Cowboys 27, Giants 24
Monday Night Football
Denver Broncos at Kansas City Chiefs — 8:15 p.m. ET
The first Monday night game of the season features an AFC West rivalry.
Patrick Mahomes and the Chiefs begin another Super Bowl chase against a Denver team that believes it can challenge Kansas City for the division. This is potentially one of the most important games of the entire opening weekend.
Prediction: Chiefs 31, Broncos 20
Week 1 Game of the Week
Bills at Texans
Two AFC contenders with championship ambitions meet immediately. Josh Allen will be under pressure to deliver, while Houston gets an early opportunity to establish itself among the AFC’s elite.
